The purpose of this in vitro study was to evaluate quantitatively the abili
ty of four different filling materials to seal the orifices of root canals
as a secondary seal after root canal therapy. Forty extracted human molar t
eeth were used. The top of pulp chambers and distal halves of the roots wer
e removed using an Isomet saw. The canal orifices were temporarily sealed w
ith a gutta-percha master cone without sealer. The pulp chambers were then
treated with a self-etching primer adhesive system (Clearfil SE Bond), a we
t bonding system (One-Step), a 4-methacryloyloxyethyl trimellitate anhydrid
e adhesive system (C&B Metabond), or a reinforced zinc oxide-eugenol (IRM).
The specimens were randomly divided into four groups of 10 each. A fluid f
iltration method was used for quantitative evaluation of leakage. Measureme
nts of fluid movement were made at 2-min intervals for 8 min. The quality o
f the seal of each specimen was measured by fluid filtration immediately an
d after I day, 1 wk, and 1 month. Even after I month the resins showed an e
xcellent seal. Zinc oxide-eugenol had significantly more leakage when compa
red with the resin systems (p < 0.05). Adhesive resins should be considered
as a secondary seal to prevent intraorifice microleakage.