IMMUNOTACTOID-LIKE GLOMERULOPATHY WITH MASSIVE FIBRILLARY DEPOSITS INLIVER AND BONE-MARROW IN MONOCLONAL GAMMOPATHY

At autopsy, massive nonamyloid fibrillar deposits, immunoreactive to I gG and kappa light chain, were found in glomeruli, liver, and bone mar row of a 72-year-old woman. The patient suffered from severe nephrotic syndrome, hepatomegaly and cholestasis, normochromic anemia, and IgG kappa monoclonal gammopathy. Fibrillary glomerulopathies, most often d enoted as fibrillary glomerulonephritis or immunotactoid glomerulopath y, are generally considered to have deposits restricted to the glomeru li. However, this study indicates that fibrillary deposits may be a sy stemic manifestation of fibrillary glomerulonephritis or immunotactoid glomerulopathy, at least when the patient is suffering from a monoclo nal gammopathy.