Paravalvular leakage after mitral valve replacement: Is left atrial enlargement an additional indication for reoperation?

Citation
K. Kirali et al., Paravalvular leakage after mitral valve replacement: Is left atrial enlargement an additional indication for reoperation?, J HEART V D, 10(4), 2001, pp. 418-425
Citations number
24
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF HEART VALVE DISEASE
ISSN journal
09668519 → ACNP
Volume
10
Issue
4
Year of publication
2001
Pages
418 - 425
Database
ISI
SICI code
0966-8519(200107)10:4<418:PLAMVR>2.0.ZU;2-J
Abstract
Background and aim of the study: Prostheses used to treat heart valve disea se improve patient survival, but have certain disadvantages. Paravalvular l eakage (PVL) is a rare complication after mitral valve replacement (MVR), a nd can impair cardiac function and reduce the patient's functional capacity , depending on the degree of periprosthetic regurgitation. Methods: Between 1985 and July 1999, 2,502 patients underwent MVR with or w ithout concomitant cardiac procedures. Of these patients, 33 (18 males, 15 females; mean age 39.8 +/- 15.3 years; range: 12-62 years) had PVL of diffe ring degree. The interval between MVR and observation of PVL was 30.5 +/- 3 1.5 months (range: 1-126 months), and the period after diagnosis was 22.6 /- 31.5 months (range: 2-114 months). Fourteen patients (42.4%) underwent r eoperation (RO group), and 19 (57.6%) were followed medically (ME group). I ndications for reoperation were reduction of functional capacity, echocardi ographically proven serious mitral regurgitation, and hemolysis. Results: Reoperative mortality was 3.0% (1/33), and late mortality 3.1% (1/ 32) for all patients. Cumulative survival after PVL was 90.2 +/- 6.7% at bo th five and ten years. Annular calcification (33.0%) and infective endocard itis (18.2%) were important predictive factors for development of PVL. Only one patient required second re-do surgery. Univariate and forward stepwise logistic regression analyses showed that there was no predictor for the de velopment of severe PVL requiring a second reoperation. No difference was o bserved between left ventricular dimensions before and after periprosthetic regurgitation. The only significant finding between groups was an increase in left atrial diameter in RO patients after the development of PVL (p <0. 05). Conclusion: Among patients undergoing MVR there are no clinical features to distinguish who will develop severe PVL during follow,up. If PVL reduces t he patient's functional capacity or causes serious hemolysis, or if severe PVL is evaluated echocardiographically, then reoperation must be performed. Mild or moderate mitral regurgitation without impairment of functional cap acity may be followed medically. In asymptomatic patients, enlargement (>5% ) of the left atrial diameter following development of moderate PVL may be a valuable criterion for deciding when to reoperate.