K. Kirali et al., Paravalvular leakage after mitral valve replacement: Is left atrial enlargement an additional indication for reoperation?, J HEART V D, 10(4), 2001, pp. 418-425
Background and aim of the study: Prostheses used to treat heart valve disea
se improve patient survival, but have certain disadvantages. Paravalvular l
eakage (PVL) is a rare complication after mitral valve replacement (MVR), a
nd can impair cardiac function and reduce the patient's functional capacity
, depending on the degree of periprosthetic regurgitation.
Methods: Between 1985 and July 1999, 2,502 patients underwent MVR with or w
ithout concomitant cardiac procedures. Of these patients, 33 (18 males, 15
females; mean age 39.8 +/- 15.3 years; range: 12-62 years) had PVL of diffe
ring degree. The interval between MVR and observation of PVL was 30.5 +/- 3
1.5 months (range: 1-126 months), and the period after diagnosis was 22.6 /- 31.5 months (range: 2-114 months). Fourteen patients (42.4%) underwent r
eoperation (RO group), and 19 (57.6%) were followed medically (ME group). I
ndications for reoperation were reduction of functional capacity, echocardi
ographically proven serious mitral regurgitation, and hemolysis.
Results: Reoperative mortality was 3.0% (1/33), and late mortality 3.1% (1/
32) for all patients. Cumulative survival after PVL was 90.2 +/- 6.7% at bo
th five and ten years. Annular calcification (33.0%) and infective endocard
itis (18.2%) were important predictive factors for development of PVL. Only
one patient required second re-do surgery. Univariate and forward stepwise
logistic regression analyses showed that there was no predictor for the de
velopment of severe PVL requiring a second reoperation. No difference was o
bserved between left ventricular dimensions before and after periprosthetic
regurgitation. The only significant finding between groups was an increase
in left atrial diameter in RO patients after the development of PVL (p <0.
05).
Conclusion: Among patients undergoing MVR there are no clinical features to
distinguish who will develop severe PVL during follow,up. If PVL reduces t
he patient's functional capacity or causes serious hemolysis, or if severe
PVL is evaluated echocardiographically, then reoperation must be performed.
Mild or moderate mitral regurgitation without impairment of functional cap
acity may be followed medically. In asymptomatic patients, enlargement (>5%
) of the left atrial diameter following development of moderate PVL may be
a valuable criterion for deciding when to reoperate.