THE TRANS-GOLGI NETWORK - A LATE SECRETORY SORTING STATION

Authors
TRAUB LM KORNFELD S
Citation
Lm. Traub et S. Kornfeld, THE TRANS-GOLGI NETWORK - A LATE SECRETORY SORTING STATION, Current opinion in cell biology, 9(4), 1997, pp. 527-533
Citations number
50
Categorie Soggetti
Cell Biology
Journal title
Current opinion in cell biology → ACNP
ISSN journal
09550674
Volume
9
Issue
4
Year of publication
1997
Pages
527 - 533
Database
ISI
SICI code
0955-0674(1997)9:4<527:TTN-AL>2.0.ZU;2-B
Abstract
Proteins synthesized on membrane-bound ribosomes are transported throu gh the Golgi apparatus and, on reaching the trans-Golgi network, are s orted for delivery to various cellular destinations. Sorting involves the assembly of cytosol-oriented coat structures which preferentially package cargo into vesicular transport intermediates. Recent studies h ave shed new light on both the molecular machinery involved and the co mplexity of the sorting processes.