H. Guo et Dr. Salahub, Origin of the high basicity of 2,7-dimethoxy-1,8-bis-(dimethylamino)naphthalene: Implications for enzyme catalysis, J MOL ST-TH, 547, 2001, pp. 113-118
Density functional calculations on model systems are performed to understan
d the origin of the large increase of basicity from 1,8-bis(dimethylamino)n
aphthalene (1) to 2,7-dimethoxy-1,8-bis(dimethylamino)naphthalene (2). It i
s found that the increase of the gas-phase proton affinity (PA) on going fr
om 1 to 2 mainly comes from the relief of steric repulsions of the methoxy
groups with their neighboring amino groups as a result of protonation. It i
s suggested that this relief of the steric repulsions along with favorable
electrostatic interactions involving the methoxy groups in 2H(+) makes a ma
jor contribution to the enhanced basicity. (C) 2001 Elsevier Science B.V. A
ll rights reserved.