Seven new sesquiterpene glycosides from the root bark of Dictamnus dasycarpus

From the water-soluble constituents of the root bark of Dictamnus dasycarpu s, six new eudesmane-type sesquiterpene glycosides, dictamnosides H-M (1-6) , and a new trinorguaiane-type sesquiterpene glycoside, dictamnoside N (7), together with four known sesquiterpene glycosides, dictamnosides A (8), B (9), D (10), and G (11), were isolated. Their structures were elucidated by spectroscopic analyses and chemical evidence. In vitro tests for immunolog ical activity showed dictamnoside A (8) to possess remarkable activity in s timulating the proliferation of T-cells.