Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex

Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were i solated from the broth extract of the fungus Xylaria multiplex BCC 1111. Ch emical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC50 values of 7 and 2 mug/mL, respectively. Both 1 a nd 2 were inactive in the screening systems toward the malarial parasite Pl asmodium falciparum (at 20 mug/mL) and were not cytotoxic to BC-1 and KB ce ll lines (at 20 mug/mL).