Antillatoxin B, a neurotoxic lipopeptide from the marine cyanobacterium Lyngbya majuscula

Authors
Nogle, LM Okino, T Gerwick, WH
Citation
Lm. Nogle et al., Antillatoxin B, a neurotoxic lipopeptide from the marine cyanobacterium Lyngbya majuscula, J NAT PROD, 64(7), 2001, pp. 983-985
Citations number
16
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
7
Year of publication
2001
Pages
983 - 985
Database
ISI
SICI code
0163-3864(200107)64:7<983:ABANLF>2.0.ZU;2-P
Abstract
Bioassay-guided fractionation of organic extracts from two Lyngbya majuscul a collections led to the isolation of a new secondary metabolite, antillato xin B, an unusual N-methyl homophenylalanine analogue of the potent neuroto xin antillatoxin. Its structure was deduced from 2D NMR and data comparison s with antillatoxin. Antillatoxin B exhibited significant sodium channel-ac tivating (EC50 = 1.77 muM) and ichthyotoxic (LC50 = 1 muM) properties.