Severe preeclampsia in antithrombin III deficiency with no history of venous thromboembolism

Citation
L. Gammaro et al., Severe preeclampsia in antithrombin III deficiency with no history of venous thromboembolism, J NEPHROL, 14(4), 2001, pp. 312-315
Citations number
29
Categorie Soggetti
Urology & Nephrology
Journal title
JOURNAL OF NEPHROLOGY
ISSN journal
11218428 → ACNP
Volume
14
Issue
4
Year of publication
2001
Pages
312 - 315
Database
ISI
SICI code
1121-8428(200107/08)14:4<312:SPIAID>2.0.ZU;2-5
Abstract
Complications of pregnancy, such as preeclampsia, placental abruption, feta l growth retardation, stillbirth and fetal death are associated with an inc reased frequency of pro-thrombotic abnormalities. We describe a case of sev ere preeclampsia and multiple placental infarctions in a 28-year-old woman at 31 weeks' gestation. Despite a negative personal history for venous thro mboembolism, coagulation screening for thrombophilia detected an isolated a ntithrombin III deficiency. In view of the high prevalence of pro-thromboti c complications, laboratory screening for thrombophilia would be advantageo us in women with complicated pregnancies, to ensure adequate management in high-risk situations, as suggested by larger-scale clinical investigations.