Citation
Ht. Yang et al., Genetic linkage analysis of the antibody responses to myelin basic proteinand myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate, J NEUROIMM, 117(1-2), 2001, pp. 21-29
Citations number
37
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROIMMUNOLOGY
ISSN journal
01655728
→ ACNP
Volume
117
Issue
1-2
Year of publication
2001
Pages
21 - 29
Database
ISI
SICI code
0165-5728(20010702)117:1-2<21:GLAOTA>2.0.ZU;2-5
Abstract
The genetic control of the antibody response to myelin basic protein (MBP)
and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 cro
sses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA
rats were highly susceptible to encephalomyelitis and made antibody respons
es to both MBP and MOG, whereas the E3 rats were disease-resistant and resp
onded only to MOG. The anti-MBP response was mainly controlled by the disea
se-promoting MHC region of the DA strain together with several disease loci
outside MHC. ln contrast, the anti-MOG response was associated with loci n
ot related to or actually conferring resistance to disease. (C) 2001 Elsevi
er Science B.V. All rights reserved.