Brain-derived gangliosides suppress the chronic relapsing-remitting experimental autoimmune encephalomyelitis in NOD mice induced with myelin oligodendrocyte glycoprotein peptide

Authors
Sekiguchi, Y Ichikawa, M Inoue, A Itoh, M Koh, CS
Citation
Y. Sekiguchi et al., Brain-derived gangliosides suppress the chronic relapsing-remitting experimental autoimmune encephalomyelitis in NOD mice induced with myelin oligodendrocyte glycoprotein peptide, J NEUROIMM, 116(2), 2001, pp. 196-205
Citations number
54
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROIMMUNOLOGY
ISSN journal
01655728 → ACNP
Volume
116
Issue
2
Year of publication
2001
Pages
196 - 205
Database
ISI
SICI code
0165-5728(20010601)116:2<196:BGSTCR>2.0.ZU;2-Y
Abstract
Chronic relapsing-remitting experimental autoimmune encephalomyelitis (CREA E) induced with myelin oligodendrocyte glycoprotein peptides 35-55 (MOG(35- 55)) in NOD mice was successfully treated with brain-derived gangliosides ( GA). The GA treatment suppressed the development and severity of CREAE, bot h clinically and histologically. Spleen cells from the GA-treated mice disp layed markedly inhibited levels of MOG(35-55) specific proliferation and in terferon-gamma production. Delayed-type hypersensitivity reactions to MOG(3 5-55) were suppressed by the GA treatment. GA modulate various T cell effec tor functions in CREAE and may be an effective therapeutic agent for autoim mune demyelinating diseases such as multiple sclerosis. (C) 2001 Elsevier S cience B.V. All rights reserved.