Investigation of serum response to PMP22, connexin 32 and P-0 in inflammatory neuropathies

Authors
Kwa, MSG van Schaik, IN Brand, A Baas, F Vermeulen, M
Citation
Msg. Kwa et al., Investigation of serum response to PMP22, connexin 32 and P-0 in inflammatory neuropathies, J NEUROIMM, 116(2), 2001, pp. 220-225
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROIMMUNOLOGY
ISSN journal
01655728 → ACNP
Volume
116
Issue
2
Year of publication
2001
Pages
220 - 225
Database
ISI
SICI code
0165-5728(20010601)116:2<220:IOSRTP>2.0.ZU;2-O
Abstract
We investigated serological immune responses against three major peripheral nerve myelin constituents in patients with immune-mediated neuropathies. C onnexin 32 (Cx32), myelin protein zero (MPZ. P-0) and peripheral myelin pro tein 22 (PMP22) were produced in Chinese hamster ovary (CHO)-K1 cells. From a panel of 25 Guillain-Barre syndrome (GBS) and 24 chronic inflammatory de myelinating polyneuropathy (CIDP) patients, only two patients showed reacti vity towards Cx32 and P-0. (C) 2001 Elsevier Science B.V. All rights reserv ed.