Controlled ovarian hyperstimulation - Relationship of early serum E-2 levels to the ultimate response of oocyte donors

OBJECTIVE: To assess the predictive value of measuring serum day 5 E-2 and in vitro fertilization (IVF) cycle outcome of oocyte donors undergoing cont rolled ovarian hyperstimulation (COH). STUDY DESIGN: Retrospective data analysis. RESULTS: Day 5 E-2 significantly correlated with the peak serum E-2 and num ber of retrieved mature oocytes. The pregnancy rates associated with stimul ated day 5 E-2 >70 pg/mL were significantly greater than in cycles with lev els < 70 pg/mL (58%, 71/123, versus 25%, 15/60; P < .05). CONCLUSION: The cycle performance of an oocyte donor can be predicted by me asuring cycle day 5 serum E-2 during COH. Poor-prognosis cycles can be iden tified and discontinued, saving patients and the program unnecessary espens e.