EFFECT OF CLODRONATE ON CALCIDIOL SERUM LEVELS IN WOMEN WITH BREAST-CANCER

Bisphosphonates have been used in multiple bone alterations characteri zed by a bone remodeling increase, such as Paget's disease, metastatic bone disease, malignant hypercalcaemia, and osteoporosis [1, 2]. Alth ough it has been proven that treatment with some bisphosphonates in os teoporosis produces an increase in bone density and a reduction of the fracture incidence [3], there is some concern that extended treatment could result in osteomalacia [4, 5]. Vitamin D deficiency is the main cause of osteomalacia and it has been proven that there is a positive relationship between vitamin D and bone density [6]. It is also known that vitamin D deficient patients have a higher risk of hip fracture. Various studies have been performed on the effect of bisphosphonates on vitamin D metabolites in patients with Paget's disease or in normal subjects after acute or short-term administration of bisphosphonates [7-9]. The goal of this study is to evaluate the short- and midterm ef fect of clodronate on vitamin B metabolites.