Idiopathic disseminated intracytoplasmic neuronal vacuolation in a neonatal Holstein calf born in the USA

Citation
An. Hamir et al., Idiopathic disseminated intracytoplasmic neuronal vacuolation in a neonatal Holstein calf born in the USA, J VET D INV, 13(4), 2001, pp. 349-351
Citations number
22
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
ISSN journal
10406387 → ACNP
Volume
13
Issue
4
Year of publication
2001
Pages
349 - 351
Database
ISI
SICI code
1040-6387(200107)13:4<349:IDINVI>2.0.ZU;2-F
Abstract
Histopathologic, immunohistochemical, and ultrastructural. evaluations were made of a 6-day-old Holstein calf with severe vacuolation of the neuronal perikarya that was widely distributed throughout the central nervous system . No evidence of storage material within the vacuoles. was revealed by hist opathologic and ultrastructural. examinations. Immunohistochemical and elec tron microscopic examinations were negative for protease-resistant prion pr otein and scrapie-associated fibrils, respectively. These results indicate that the clinical signs in this calf were not associated with transmissible spongiform encephalopathy. Neuronal vacuolation has not previously been do cumented in calves.