An. Hamir et al., Idiopathic disseminated intracytoplasmic neuronal vacuolation in a neonatal Holstein calf born in the USA, J VET D INV, 13(4), 2001, pp. 349-351
Histopathologic, immunohistochemical, and ultrastructural. evaluations were
made of a 6-day-old Holstein calf with severe vacuolation of the neuronal
perikarya that was widely distributed throughout the central nervous system
. No evidence of storage material within the vacuoles. was revealed by hist
opathologic and ultrastructural. examinations. Immunohistochemical and elec
tron microscopic examinations were negative for protease-resistant prion pr
otein and scrapie-associated fibrils, respectively. These results indicate
that the clinical signs in this calf were not associated with transmissible
spongiform encephalopathy. Neuronal vacuolation has not previously been do
cumented in calves.