Eight different diets were each fed to 6 cats to evaluate the effect on a g
uaiac and an o-tolidine fecal occult blood test. Fecal samples were collect
ed from day 5 through day 7. Canine blood or pure cottage cheese were used
as positive and negative controls, respectively. One hundred thirty-four fe
cal samples were analyzed. The dry fish (capelin) and vegetable (tapioca) d
iet and the pure cottage cheese diet had only negative results in both test
s, whereas a canned chicken and cereal (rice) diet had negative results in
all fecal samples in the o-tolidine tablet test and in 10 of 16 fecal sampl
es in the guaiac paper test. All other fecal samples from cats eating 6 oth
er diets and the canine blood additive were positive in both fecal occult b
lood tests. These results indicate that occult blood tests based on o-tolid
ine and guaiac are clinically useful, but cats need to be on a strict diet
before the tests are used.