Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice

Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V+ and I CSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma, and leukemia. Lymp homa types included precursor T-cell and B-cell lymphoblastic, small lympho cytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts o r immunoblasts, two additional subtypes are defined here: lymphoblastic lym phoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements. Published by Elsevier Science Ltd.