In this article, a method for phased array combining is formulated which ma
y be used to cancel ghosts caused by a variety of distortion mechanisms, in
cluding space variant distortions such as local flow or off-resonance. This
method is based on a constrained optimization, which optimizes SNR subject
to the constraint of nulling ghost artifacts at known locations. The resul
tant technique is similar to the method known as sensitivity encoding (SENS
E) used for accelerated imaging; however, in this formulation it is applied
to full field-of-view (FOV) images. The method is applied to multishot EPI
with noninterleaved phase encode acquisition. A number of benefits, as com
pared to the conventional interleaved approach, are reduced distortion due
to off-resonance, in-plane flow, and EPI delay misalignment, as well as eli
minating the need for echo-shifting. Experimental results demonstrate the c
ancellation for both phantom as well as cardiac imaging examples. Published
2001 Wiley-Liss, Inc.(dagger)