Expression analysis of the histamine H-3 receptor in developing rat tissues

Citation
A. Heron et al., Expression analysis of the histamine H-3 receptor in developing rat tissues, MECH DEVEL, 105(1-2), 2001, pp. 167-173
Citations number
35
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
09254773 → ACNP
Volume
105
Issue
1-2
Year of publication
2001
Pages
167 - 173
Database
ISI
SICI code
0925-4773(200107)105:1-2<167:EAOTHH>2.0.ZU;2-X
Abstract
Endogenous histamine is involved in tissue growth and cell proliferation. I n accordance with a putative function of the H-3 receptor in this mitogenic effect, we show that H-3-receptor mRNAs are expressed together with those of the histamine-synthesizing enzyme in the embryonic liver and adipose tis sue, and in various epithelia. Finally, we show that activation of recombin ant H3 receptors enhances MAP kinase activity. (C) 2001 Elsevier Science Ir eland Ltd. All rights reserved.