L. Blanchon et al., Co-localization of KLF6 and KLF4 with pregnancy-specific glycoproteins during human placenta development, MECH DEVEL, 105(1-2), 2001, pp. 185-189
Pregnancy-specific glycoproteins (PSGs) are major placental proteins essent
ial for the maintenance of normal gestation. However, little is known about
their gene expression regulation during placentation. It was previously de
monstrated that the human core promoter binding protein recently renamed Kr
uppel-like factor (KLF) 6 binds to a highly conserved sequence within the P
SG promoters and is mainly expressed in human term placenta. Here, we deter
mined the expression pattern of the 13 other KLFs during human placental de
velopment. We demonstrate that eight KLFs exhibit specific expression patte
rns in human placental tissues and membranes, in favor of a functional coop
eration of specific KLFs during placentation. In addition, wt: demonstrate
that KLF6, KLF4 and PSG proteins are co-expressed in same cell types of pla
cental villi and membranes. This experimental evidence further strengthens
the potential cross talk of both transcription factors for PSG gene regulat
ion in vive. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.