Co-localization of KLF6 and KLF4 with pregnancy-specific glycoproteins during human placenta development

Citation
L. Blanchon et al., Co-localization of KLF6 and KLF4 with pregnancy-specific glycoproteins during human placenta development, MECH DEVEL, 105(1-2), 2001, pp. 185-189
Citations number
30
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
09254773 → ACNP
Volume
105
Issue
1-2
Year of publication
2001
Pages
185 - 189
Database
ISI
SICI code
0925-4773(200107)105:1-2<185:COKAKW>2.0.ZU;2-2
Abstract
Pregnancy-specific glycoproteins (PSGs) are major placental proteins essent ial for the maintenance of normal gestation. However, little is known about their gene expression regulation during placentation. It was previously de monstrated that the human core promoter binding protein recently renamed Kr uppel-like factor (KLF) 6 binds to a highly conserved sequence within the P SG promoters and is mainly expressed in human term placenta. Here, we deter mined the expression pattern of the 13 other KLFs during human placental de velopment. We demonstrate that eight KLFs exhibit specific expression patte rns in human placental tissues and membranes, in favor of a functional coop eration of specific KLFs during placentation. In addition, wt: demonstrate that KLF6, KLF4 and PSG proteins are co-expressed in same cell types of pla cental villi and membranes. This experimental evidence further strengthens the potential cross talk of both transcription factors for PSG gene regulat ion in vive. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.