A successful free tissue transfer of serratus anterior muscle, to provide c
overage for an open ankle defect in a pregnant patient, is described. Micro
vascular surgery in the presence of a viable pregnancy demands consideratio
ns unique to this situation. Although rarely possible, an attempt should be
made to plan surgery to coincide with the second trimester, to lessen the
risk of anesthesia to the fetus. Maternal positioning, fluid balance, and a
spiration precautions need to be critically addressed. Close perioperative
monitoring by an obstetrician is essential. The condition of pregnancy resu
lts In a hypercoagulable state that may lead to an increased risk of anasto
motic, failure. The use of anticoagulants results in increased risk of blee
ding, not only for the patient but also for the fetus, as well as risk of t
eratogenic effects. Closely monitored heparin is considered safe in pregnan
cy as is low-molecular-weight dextran and low-dose aspirin. Additional cons
iderations include the use of narcotics and sedatives for comfort postopera
tively, as well as antibiotic choices, if Indicated. (C) 2001 Wiley-Liss, I
nc.