A significant recent development in functional magnetic resonance imaging (
MRI) is the introduction of event-related fMRI, also known as time-resolved
fMRI. Because the exact shape of the MR response in an event-related MM ex
periment is often not known, traditional methods developed for block design
experiments, such as t test and correlation analysis, are not well-suited
for extracting activated pixels from the event-related data. In this work,
a statistical technique based on nonadditive two-way analysis of variance i
s developed for use in event-related studies. Theoretical and experimental
work were carried out for establishing a statistical threshold to determine
pixel activation. Experimental studies were performed to demonstrate the u
tility of this approach. (C) 2001 Academic Press.