Recruitment of activated microglia cells in the spinal cord of mice by ALSIgG

Mice were injected Lp. with IgG samples of different patients to test wheth er IgG from amyotrophic lateral sclerosis (ALS) can initiate an immune/infl ammatory reaction targeting motor neurons. All IgG samples of five ALS pati ents and none of the disease controls recruited activated microglia cells i n the ventral horn of the spinal cord. CD3 lymphocytes were not accumulated in the same tissue. Similar reaction was evoked by injection of IgG from g uinea pigs with experimental autoimmune gray matter disease (EAGMD) induced by immunization with the homogenate of the ventral horn of bovine spinal c ord. The results indicate that ALS IgG and anti-motoneuron IgG induce micro glia reaction targeting motor neurons without initiating T cell response in the recipient mice. NeuroReport 12:2449-2452 (C) 2001 Lippincott Williams & Wilkins.