F. Velasco et al., Electrical stimulation of the prelemniscal radiation in the treatment of Parkinson's disease: An old target revised with new techniques, NEUROSURGER, 49(2), 2001, pp. 293-306
OBJECTIVE: In the treatment of tremor and rigidity in patients with Parkins
on's disease (PD), the prelemniscal radiation (RAPRL), a subthalamic bundle
of fibers, is an exquisite target that can be visualized easily on ventric
ulograms. We sought to evaluate the effect of electrical stimulation of the
RAPRL on symptoms and signs of PD in a long-term trial and to determine th
e localization of the stimulated area by means of stereotactic magnetic res
onance imaging studies.
METHODS: Ten patients with PD predominantly on one side had tetrapolar elec
trodes stereotactically oriented through a frontal parasagittal approach to
the RAPRL contralateral to the most prominent symptoms. Preoperative and p
ostoperative evaluations at 3, 6, 9, and 12 months after surgery were perfo
rmed using conventional PD scales and quantitative evaluations of tremor am
plitude and reaction time. Stereotactic high-resolution magnetic resonance
imaging studies with the electrodes in place were used for anatomic localiz
ation.
RESULTS: In all patients, temporary suppression of tremor occurred when the
electrodes reached the target. The most effective stimulation was obtained
when the pair of contacts was placed in the RAPRL. Long-term stimulation a
t 130 Hz, 0.09 to 0.450 milliseconds and 1.5 to 3.0 V produced significant
improvement in tremor and rigidity and mild improvement in bradykinesia.
CONCLUSION: The RAPRL is an effective target for the alleviation of tremor
and rigidity in patients with PD by either lesioning or neuromodulation; ho
wever, neuromodulation has the advantage of not inducing an increase in bra
dykinesia. The stimulated area seems to be independent of the subthalamic n
ucleus.