Photodynamic therapy of head and neck cancer

Photodynamic therapy (PDT) is an alternative treatment option for tumours o f the head and neck. The principle of PDT is based on a photochemical react ion which is initiated by light activation of a photosensitizing drug causi ng tumour cell death. PDT damage heals mainly by regeneration rather than s carring. Due to this organ-preserving principle of PDT, important structure s are maintained with very good functional and cosmetic outcome. This artic le will review the principle of PDT and the different indications for PDT o f tumours of the head and neck, focusing on small and advanced tumours of t he oral cavity and the larynx as well as papillomatosis of the larynx. A cr itical review on the literature will be accomplished.