Effect of fasciolicides on the antigenaemia in sheep naturally infected with Fasciola hepatica

A study was developed to evaluate the influence of triclabendazole (Fasinex ) and netobimin (Hapasil) the antigenaemia in sheep naturally infected with Fasciola hepatica during 16 weeks. A sandwich-ELISA (enzyme-linked immunos orbent assay) using a rabbit polyclonal IgG antibody to F. hepatica antigen s was employed and the data obtained were compared to those from coprologic al and indirect-ELISA techniques. Triclabendazole reduced the values of cir culating antigens at weeks 2-4 post-treatment and faecal output at weeks 2- 8 posttreatment, but antibodies showed positive values until the end of the study. Netobimin did not reduce circulating antigens of the trematode nor egg-excretion; and IgG antibodies did not decrease throughout the study.