Three patients with a mean age of 69 years presented with endometrioid carc
inoma of the prostate between 1995 and 2000. With a mean follow-up of 17 mo
nths, 2 patients are alive without metastases and I has died from another c
ause. Endometrioid carcinoma represents less than 5% of all prostate cancer
s. Its histological origin has been the subject of controversy for a long t
ime. The clinical presentation is often unusual and the natural history is
considered to be more aggressive than that of the glandular form of prostat
ic cancer. Endometrioid carcinoma of the prostate is not derived from Mulle
rian structures, but from prostatic tissue. It is an unusual form of prosta
tic cancer whose clinical course and treatment are the same as those of ade
nocarcinoma.