Objective: The goal of the study was to examine the utility of Creamer's co
gnitive processing theory of trauma in a sample of individuals undergoing t
reatment for cancer. This theory proposes that avoidance is a maladaptive s
trategy of dealing with intrusive thoughts about a traumatic experience and
suggests that avoidance mediates the relation between intrusive thoughts a
nd later psychological distress. The role of disease-related factors, speci
fically changes in physical impairment and disease stage, was also examined
. Methods: Patients (N = 189) undergoing treatment for cancer completed que
stionnaires at three time points, spaced 3 months apart. Intrusive thoughts
, functional impairment, and psychological distress were assessed at Time 1
, avoidance and functional impairment at Time 2, and psychological distress
was assessed again at Time 3. The fit of the model was tested separately f
or patients with early-stage (stages 1 and 2) and late-stage (stages 3 and
4) disease. Results: The mediational role for avoidance was supported among
patients with advanced stages of cancer but not for patients with early-st
age disease. Results were inconsistent with predictions about the role of p
hysical impairment. Among individuals with late-stage cancer, changes in fu
nctional impairment were not predictive of greater avoidance, and impairmen
t had a significant but weak effect on the change in distress. Among patien
ts with early-stage cancer, a deterioration in physical impairment was asso
ciated with increases in avoidance, and deterioration in physical impairmen
t increased distress. Conclusions: The results of this study were partially
consistent with Creamer's cognitive processing theory. A moderating effect
was found for disease stage on associations between intrusions, avoidance,
physical impairment, and distress.