THE NOVEL SUBSTITUTED ACYLPROLINE-CONTAINING DIPEPTIDE, GVS-111, PROMOTES THE RESTORATION OF LEARNING AND MEMORY-IMPAIRED BY BILATERAL FRONTAL LOBECTOMY IN RATS

The present study investigated the potential benefit of the ethyl eate r of N-phenylacetylprolylglycine (GVS-111) on the model of bilateral f rontal lobectomy (BFL) in rats. The animals in Experiment 1 were train ed in an active avoidance task and subsequently underwent BFL. The ani mals in Experiment 2 were first assessed in an open field and in a pas sive avoidance test before the BFL was performed. BFL dramatically dec reased performance in the active avoidance test, disturbed habituation of horizontal activity in the open field and diminished the latency t o enter the dark compartment in the passive avoidance test. GVS-111, a dministered in a dose of 0.5 mg/kg/day i.p. for 9 days following the o peration, was found to improve performance in both active avoidance an d passive avoidance and restored habituation of horizontal activity in the lobectomized animals.