SYNTHESIS OF TRITIUM, DEUTERIUM, AND C-14-LABELED N-ETHYL-N-METHYL-3-[1(DIMETHYLAMINO)ETHYL]CARBAMIC ACID, PHENYL ESTER, (L)-2,3-DIHYDROXYBUTANEDIOIC ACID SALT (SDZ ENA-713 HTA), AN INVESTIGATIONAL DRUG FOR THE TREATMENT OF ALZHEIMERS-DISEASE

Authors
CISZEWSKA G PFEFFERKORN H TANG YS JONES L TARAPATA R SUNAY UB
Citation
G. Ciszewska et al., SYNTHESIS OF TRITIUM, DEUTERIUM, AND C-14-LABELED N-ETHYL-N-METHYL-3-[1(DIMETHYLAMINO)ETHYL]CARBAMIC ACID, PHENYL ESTER, (L)-2,3-DIHYDROXYBUTANEDIOIC ACID SALT (SDZ ENA-713 HTA), AN INVESTIGATIONAL DRUG FOR THE TREATMENT OF ALZHEIMERS-DISEASE, Journal of labelled compounds & radiopharmaceuticals, 39(8), 1997, pp. 651-668
Citations number
33
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
8
Year of publication
1997
Pages
651 - 668
Database
ISI
SICI code
0362-4803(1997)39:8<651:SOTDAC>2.0.ZU;2-Y
Abstract
-Ethyl-N-methyl-3-[1-(dimethylamino)ethyl]carbamic acid, phenyl-2-H-3- ester, (L)-2,3-dihydroxybutanedioic acid salt was synthesized via dire cted ortho-metallation methodology. ethyl-3-[1-(di-(H-2(3))-methylamin o)ethyl]carbamic acid, phenyl ester, (L)-2,3-dihydroxybutanedioic acid salt was synthesized from 3-hydroxyacetophenone. The molecule was res olved by classical diastereomeric salt formation and fractional crysta llization The carbon-14 analog, -methyl-3-[1-(dimethylamino)ethyl-1-(C -14)carbamic acid, phenyl ester, (L)-2,3-dihydroxybutanedioic acid sal t was constructed starting from 3-iodoamisole and featured the enantio selective reduction of a methoxylamine intermediate.