SYNTHESIS OF I-131 DERIVATIVES OF INDOLEALKYLAMINES FOR BRAIN MAPPING

The synthesis and spectral properties of new radioiodinated indolealky lamines like 2-[I-131]-iodo-N,N-dimethyltryptamine, 2-[I-131]-iodo-N-m ethyltryptamine, 2-[I-131]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[I -131]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[I-131]-iodo-bufotenine ), and 2-[I-131]-iodo-tryptamine and the known 2-[I-131]-iodo-N-acetyl -5-methoxy-tryptamine (2-[I-131]-iodo-melatonine) are described herein . These were synthesized by a high-yield novel method, and their spect ral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.