SYNTHESES OF [21-C-11] AND (21-C-13)PROGESTERONE

Authors
LIDSTROM P NEU H LANGSTROM B
Citation
P. Lidstrom et al., SYNTHESES OF [21-C-11] AND (21-C-13)PROGESTERONE, Journal of labelled compounds & radiopharmaceuticals, 39(8), 1997, pp. 695-704
Citations number
28
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
8
Year of publication
1997
Pages
695 - 704
Database
ISI
SICI code
0362-4803(1997)39:8<695:SO[A(>2.0.ZU;2-3
Abstract
[21-C-11]Progesterone was synthesised via the cross-coupling 17 beta-c arboxylic acid chloride-4-androsten-3-one with lithium [C-11]methyl(2- thienyl)cuprate (LiCN). The title compound was obtained in 30-35% deca y corrected radiochemical yield, based on [C-11]methyl iodide, within 35 minutes after end of radionuclide production. The specific radioact ivity was 14 GBq/mu mole. (21-C-13)Progesterone vias synthesised using the same procedure for determination of the position of the label.