Two-fragment alpha-adrenolytics - 4. Synthesis of phosphorylated derivatives of 2-aryloxyethylamines and N-phenylpiperazine

The reactions of 3-chloropropylphosphonates, 3-chloropropylthiophosphonates , or 3-chloropropylphosphinates with 2-aryloxyethylamines or N-phenylpipera zine afford the corresponding 3-(2-aryloxyethylamino)propylphosphonates and -phosphinates or 3-(4-phenylpiperazin-1-yl)propylphosphonates and -phosphi nates. The compounds obtained exhibit alpha -adrenolytic and hypotensive ac tivities, the latter being found to depend on the substituents at the P ato m.