Reconciling differences in effective solute removal between intermittent and continuous therapies

Solute removal by various forms of renal replacement therapy (RRT) differs from that occurring in the native kidney in several ways. Among the dialyti c therapies, the relationship between clearance and mass removal rate may d iffer substantially. The purpose of this article is to review the various a pproaches that have been proposed to account for this differing relationshi p among the various types of RRT. Specific quantitative approaches along wi th clinical applications are provided.