A short procedure for synthesis of 4-ethynyl-2,2,6,6-tetramethyl-3,4-dehydro-piperidine-1-oxyl nitroxide

Authors
Gannett, PM Darian, E Powell, JH Johnson, EM
Citation
Pm. Gannett et al., A short procedure for synthesis of 4-ethynyl-2,2,6,6-tetramethyl-3,4-dehydro-piperidine-1-oxyl nitroxide, SYN COMMUN, 31(14), 2001, pp. 2137-2141
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
14
Year of publication
2001
Pages
2137 - 2141
Database
ISI
SICI code
0039-7911(2001)31:14<2137:ASPFSO>2.0.ZU;2-H
Abstract
The spin-probe labeling technique has been applied to DNA and offers the po ssibility of studying antisense agents in cells. Simpler syntheses of spin- probes for incorporation into DNA would facilitate this. Here, we describe the synthesis of a new spin probe that requires half the number of steps of related 5 ring nitroxide.