A shortcut to the smaller fragment of pamamycin-607

Authors
Bernsmann, H Gruner, M Frohlich, R Metz, P
Citation
H. Bernsmann et al., A shortcut to the smaller fragment of pamamycin-607, TETRAHEDR L, 42(32), 2001, pp. 5377-5380
Citations number
55
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
32
Year of publication
2001
Pages
5377 - 5380
Database
ISI
SICI code
0040-4039(20010806)42:32<5377:ASTTSF>2.0.ZU;2-0
Abstract
Starting from a key intermediate for the synthesis of the larger hydroxy ac id constituent of pamamycin-607 (1), an efficient three-step route to the m ethyl ester of the smaller fragment of I involving a Yamaguchi lactonizatio n with concomitant C(2) epimerization was developed. Alternatively, the met hyl ester of the smaller hydroxy acid portion of I was prepared by direct C (2) epimerization. (C) 2001 Elsevier Science Ltd. All rights reserved.