Carbohydrate-based routes to salicylate natural products: formal total synthesis of (+)-apicularen A from D-glucal

Authors
Lewis, A Stefanuti, I Swain, SA Smith, SA Taylor, RJK
Citation
A. Lewis et al., Carbohydrate-based routes to salicylate natural products: formal total synthesis of (+)-apicularen A from D-glucal, TETRAHEDR L, 42(32), 2001, pp. 5549-5552
Citations number
30
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
32
Year of publication
2001
Pages
5549 - 5552
Database
ISI
SICI code
0040-4039(20010806)42:32<5549:CRTSNP>2.0.ZU;2-L
Abstract
A synthesis of apicularen analogue (-)-4 in 18 steps from D-glucal is repor ted. As (+)-4 has been converted into apicularen A in 8 steps, this constit utes a formal total synthesis of this potent naturally occurring anti-cance r agent. (C) 2001 Elsevier Science Ltd. All rights reserved.