Uterine tumor resembling ovarian sex-cord tumor - a case report and reviewof the literature

A uterine tumor resembling an ovarian sex-cord tumor (UTROSCT) is a very ra re lesion with only 38 cases reported in the literature so far. Here, we sh ow an additional case of a pure UTROSCT with a DNA stemline at Ic in a 49-y ear-old woman presenting with abnormal vaginal bleeding. Problems in differ ential diagnosis arise mainly due to the variable histological picture of U TROSCT. Immunohistochemically, these tumors express cytokeratin, epithelial membrane antigen, vimentin, and smooth muscle actin. Moreover, in some cas es, CD99 and alpha -inhibin are detectable. Although 36% of UTROSCT have in filtrative margins, almost all of them behave benignly. It is thus question able whether the same prognostic criteria apply for these tumors as for end ometrial stromal sarcomas. However, in the so-called mixed UTROSCT, the end ometrial stromal sarcoma component determines the outcome.