Insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in cystic fibrosis: a positive effect of antibiotic therapy and hyperalimentation
J. Lebl et al., Insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in cystic fibrosis: a positive effect of antibiotic therapy and hyperalimentation, ACT PAEDIAT, 90(8), 2001, pp. 868-872
Patients with cystic fibrosis (CF) are underweight and growth retarded. Thi
s study tested the link between serum insulin-like growth factor-I (IGF-I)
and insulin-like growth factor-binding protein-3 (IGFBP-3) levels and body
height, nutritional status, pulmonary function tests and activity of inflam
mation in 92 subjects with CF (age 2.1-18.8 y). It also analysed the effect
of short-term antibiotic treatment and hyperalimentation on IGF-I and IGFB
P-3 levels in 33 subjects (age 3.6-33.7 y) on 41 occasions. Both IGF-I (-1.
19 +/- 0.17 SD) and IGFBP-3 levels (-0.66 +/- 0.12 SID; both p < 0.0001 vs
0) were decreased in cross-sectional measurements. Their standardized value
s were inversely proportional to age (IGF-I r = -0.23, p = 0.03; IGFBP-3: r
= -0.29, p = 0.005) and positively correlated with SIDS of height (IGF-I:
r = 0.40, p < 0.0001; IGFBP-3: r = 0.36, p = 0.0005) and of mid-arm circumf
erence (IGF-I: r = 0.39, p = 0.0001; IGFBP-3: r = 0.38, p = 0.0002), and wi
th pulmonary function tests. After a short-term course of intensive antibio
tic therapy and hyperalimentation, IGF-I normalized (from -0.66 +/- 0.20 to
0.00 +/- 0.25 SD; p < 0.0001) and IGFBP-3 increased (from -0.78 +/- 0.15 t
o -0.53 +/- 10.16 SD; p = 0.002). IGFBP-3 correlated inversely with erythro
cyte sedimentation rate (r = -0.40, p = 0.01).
Conclusion: The levels of IGF-I and IGFBP-3 are markedly decreased in patie
nts with CF and tend to normalise after a short course of antibiotic treatm
ent and hyperalimentation.