Tick-borne diseases are the most common vector-borne illnesses in the Unite
d States. Lyme disease is the most common, but several others also occur. T
he ehrlichioses have only been identified as agents of human disease in the
United States in the past few decades, and knowledge about them is still e
volving. Rocky Mountain spotted fever is relatively common and can be sever
e, especially in children, if the diagnosis is not made quickly. Tularemia
has long been known to cause disease in humans, but there is renewed intere
st because of its potential as a biologic warfare agent. These diseases can
be severe or even fatal. Most of them are easily treatable when identified
early. These diseases result from a variety of infectious agents including
bacteria, rickettsia, viruses and protozoa, or they may be caused by subst
ances produced by the tick. Most of these diseases present initially with n
onspecific symptoms and are often difficult to recognize. Few definitive di
agnostic tests are available. Therefore, knowledge of the epidemiology and
common presentations, as well as the diagnostic options and treatments avai
lable, are important issues for family physicians.