Stability of Adderall in extemporaneously compounded oral liquids

The short-term stability of Adderall in three extemporaneously compounded o ral liquids was studied. Three suspensions of Adderall 1 mg/mL were prepared from commercially avail able 10-mg Adderall tablets with Ora-Sweet, Ora-Plus, and a 1:1 mixture of Ora-Sweet and Ora-Plus. Each suspension was stored in the dark in a stabili ty chamber at 25 degreesC and 60% relative humidity for 30 days. The stabil ity of the active drug (a mixture of levoamphetamine and dextroamphetamine salts) in each of the three vehicles was determined immediately after prepa ration and at 10, 20, and 30 days by using gas chromatography-mass spectrom etry (GCMS). No significant changes in concentrations of-either amphetamine isomer occur red during the 30-day study period. Visual inspection of samples revealed n o changes in color or odor. Extemporaneously compounded liquid oral formulations of Adderall 1 mg/mL in Ora-Sweet, Ora-Plus, or a 1:1 mixture of Ora-Sweet and Ora-Plus were stabl e for at least 30 days at 25 degreesC and 60% relative humidity.