Pm. Ridker et al., A prospective study of Helicobacter pylori seropositivity and the risk forfuture myocardial infarction among socioeconomically similar US men, ANN INT MED, 135(3), 2001, pp. 184-188
Citations number
20
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Background: The role of Helicobacter pylori as a determinant of cardiovascu
lar disease is controversial.
Objective: To determine whether previous exposure to H. pylori is associate
d with an increased risk for myocardial infarction.
Design: Prospective case-control study.
Setting: Physicians' Health Study.
Participants: Initially healthy U.S. men.
Measurements: Titers of IgG antibody against H. pylori and several inflamma
tory markers were measured in baseline blood samples obtained from 445 men
who subsequently had a myocardial infarction (case-patients) and 445 men ma
tched for age and smoking status who remained free of vascular disease (con
trols) during a mean follow-up of 8.9 years.
Results: Baseline seropositivity was similar among case-patients and contro
ls (43.4% vs. 44.3%; rate ratio, 0.96 [95% Cl, 0.7 to 1.3]). Minimal eviden
ce of association was found between magnitude of seropositivity and subsequ
ent risk and between seropositivity and levels of the inflammatory biomarke
rs.
Conclusion: in a socioeconomically homogeneous population, we found limited
evidence of association between H. pylori exposure and risk for future myo
cardial infarction.