Cx. Zhao et Pl. Polavarapu, Comparative evaluation of vibrational circular dichroism and optical rotation for determination of enantiomeric purity, APPL SPECTR, 55(7), 2001, pp. 913-918
Vibrational circular dichroism (VCD) is used to determine enantiomeric puri
ty (EP) of three sample groups, and the results are compared with those obt
ained from optical rotation. In most typical cases EP determination from op
tical rotation is more accurate than that from VCD. However, in cases where
either optical rotation is very small or different chiral samples are pres
ent as a mixture, EP determination from VCD provides definite advantages wi
th reasonable accuracy.