Permeability barrier function of skin exposed to ionizing radiation

Objective: To characterize the epidermal permeability barrier function of s kin during exposure to ionizing radiation. Design: A prospective cohort study. Setting: University hospital medical center Patients: Fifteen women receiving local radiation therapy (5000-6000 rad [5 0-60 Gy]) following breast-conserving surgery for breast cancer. Main Outcome Measures: Clinical symptoms and transepidermal water loss (TEW L). Results: Epidermal permeability barrier function is impaired in patients wh o exhibit clinical signs of radiation dermatitis. The functional damage to the stratum corneum induced by ionizing radiation occurs with a delayed cou rse, starting within a mean period of 11 days and reaching maximal values a fter a mean period of 27 days (range, 13-75 days). The onset of TEWL increa se precedes the onset of radiation dermatitis and the maximal TEWL measurem ents precede the peak of skin changes. Patients with an early onset of TEWL increase show a longer duration of skin symptoms. Conclusions: Skin changes caused by radiation dermatitis are associated wit h an increase in TEWL. The barrier impairment is comparable to the changes observed with UV radiation exposure but exhibits an even more delayed cours e. Our results suggest that preservation of the epidermal permeability barr ier function by topical treatment may ameliorate radiation dermatitis.