Basal ganglia metabolite abnormalities in minor motor disorders associatedwith human immunodeficiency virus type 1

Background: Minor motor disorders (MMDs) associated with human immunodefici ency virus type 1 (HIV-1) predict HIV-1 dementia and death. Little is known about the time course and neuropathologic mechanisms of HIV-1 MMDs. Objective: To investigate the relationship between HIV-1 MMDs, as assessed by psychomotor speed, and metabolic alterations in the basal ganglia, as de tected by proton magnetic resonance spectroscopy. Patients and Methods: A total of 32 HIV-1-seropositive patients (10 with no MMD, 8 with incipient MMD, and 14 with sustained MMD, assessed through ele ctrophysiologic testing of psychomotor speed including contraction times; 2 9 treated with highly active antiretroviral therapy) and 14 HIV-1-seronegat ive control subjects were examined for cerebral metabolite abnormalities in the basal ganglia by means of magnetic resonance spectroscopy. Results: The 3 patient groups showed significantly different ratios of myoi nositol/creatine (P=.02) in the basal ganglia. Whereas patients with no MMD or incipient MMD showed normal ratios, patients with sustained MMD showed higher values for myoinositol/creatine as a sign of glial proliferation. No differences in N-acetyl compounds, indicative of neuronal loss, were found . Conclusion: Whereas metabolic alterations in the basal ganglia were not det ected in patients with incipient HIV-1 MMD, patients with sustained HIV-1 M MD did have significantly altered metabolic spectra indicative of glial pro liferation.