Antibody responses of healthy infants to concurrent administration of a bivalent Haemophilus influenzae type b hepatitis B vaccine with diphtheria-tetanus-pertussis, polio and measles-mumps-rubella vaccines

Objective: To confirm that children given a bivalent Haemophilus influenzae type b-hepatitis B vaccine (bivalent Hib-HB vaccine; COMVAX (TM)) concurre ntly with priming doses of diphtheria-tetanus-pertussis vaccine (DTP), a bo oster dose of diphtheria-tetanus-acellular pertussis vaccine (DTaP), inacti vated or oral polio vaccine (IPV or OPV) and measles-mumps-rubella vaccine (M-M-(RII)-I-(R)) have satisfactory antibody responses to all antigens. Design: 126 healthy 2-month-old infants were scheduled to receive bivalent Hib-HB vaccine concurrently with DTP (2 and 4 months of age), OPV or IPV (r andom allocation to OPV or IPV at 2 months of age; OPV at 4 and 14 to 15 mo nths of age), DTaP and M-M-(RII)-I-(R) (14 to 15 months of age). A response was judged, 'adequate' if the lower bound of the 95% confidence interval o n the proportion of vaccinees having a critical antibody level was < 10 per centage points below prediction. Results: Antibodies to hepatitis B virus surface antigen, H. influenzae pol ysaccharide, diphtheria toxin, tetanus toxin, pertussis agglutinogens, pert ussis toxin (as measured by enzyme immunoassay but not by Chinese hamster o vary cell assay), pertussis filamentous haemagglutinin after a booster dose of DTaP, poliovirus type 2, measles virus, and mumps virus all equalled or exceeded expected levels. Antibodies to rubella virus and pertussis filame ntous haemagglutinin (after priming doses of DTP) fell slightly, and in the case of rubella significantly, below predicted levels. Antibodies to polio virus types 1 and 3 were also below expectation after 2 doses of polio vacc ine but were adequate following a third dose of vaccine. Conclusion: Concurrent administration of bivalent Hib-HB vaccine with primi ng doses of DTP, a booster dose of DTaP, OPV, IPV, or M-M-(RII)-I-(R) was w ell tolerated and, with the possible exception of rubella, did not substant ially impair the antibody response to any antigen.