Parallel solid-phase synthesis of nucleoside phosphoramidate libraries

Authors
Jin, Y Chen, XL Cote, ME Roland, A Korba, B Mounir, S Iyer, RP
Citation
Y. Jin et al., Parallel solid-phase synthesis of nucleoside phosphoramidate libraries, BIOORG MED, 11(16), 2001, pp. 2057-2060
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
16
Year of publication
2001
Pages
2057 - 2060
Database
ISI
SICI code
0960-894X(20010820)11:16<2057:PSSONP>2.0.ZU;2-7
Abstract
Combinatorial chemistry is playing an increasingly prominent role in the pr ocess of drug discovery. A nucleic acid-based (NAB (TM)) scaffold can be en gineered to create functional group and topological diversity in a library. Described herein is the parallel solid-phase synthesis of combinatorial li braries of nucleoside phosphoramidates. and the first evaluation of antivir al activity against hepatitis B virus (HBV). (C) 2001 Elsevier Science Ltd. All rights reserved.