1,4-disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)

Authors
Heerding, DA Chan, G DeWolf, WE Fosberry, AP Janson, CA Jaworski, DD McManus, E Miller, WH Moore, TD Payne, DJ Qiu, XY Rittenhouse, SF Slater-Radosti, C Smith, W Takata, DT Vaidya, KS Yuan, CCK Huffman, WF
Citation
Da. Heerding et al., 1,4-disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI), BIOORG MED, 11(16), 2001, pp. 2061-2065
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
16
Year of publication
2001
Pages
2061 - 2065
Database
ISI
SICI code
0960-894X(20010820)11:16<2061:1IAPAA>2.0.ZU;2-Q
Abstract
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escheri chia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active si te of E. coli FabI. (C) 2001 Elsevier Science Ltd. All rights reserved.