Coupling of the antennapedia third helix to a potent antagonist of the p53/hdm2 protein-protein interaction

Authors
Garcia-Echeverria, C Furet, P Chene, P
Citation
C. Garcia-echeverria et al., Coupling of the antennapedia third helix to a potent antagonist of the p53/hdm2 protein-protein interaction, BIOORG MED, 11(16), 2001, pp. 2161-2164
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
16
Year of publication
2001
Pages
2161 - 2164
Database
ISI
SICI code
0960-894X(20010820)11:16<2161:COTATH>2.0.ZU;2-J
Abstract
The use of cell-membrane translocating sequences for intracellular delivery of peptides can be a powerful approach to validate drug discovery targets in cellular settings. To accomplish this, a protocol has been implemented t o couple the antennapedia third helix (residues 43-58) to a potent antagoni st of the p53/hdm2 protein-protein interaction without affecting its in vit ro inhibitory activity. (C) 2001 Elsevier Science Ltd. All rights reserved.