Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A novel NR1/2B subtype selective NMDA receptor antagonist

Authors
Pinard, E Alanine, A Bourson, A Buttelmann, B Gill, R Heitz, MP Jaeschke, G Mutel, V Trube, G Wyler, R
Citation
E. Pinard et al., Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A novel NR1/2B subtype selective NMDA receptor antagonist, BIOORG MED, 11(16), 2001, pp. 2173-2176
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
16
Year of publication
2001
Pages
2173 - 2176
Database
ISI
SICI code
0960-894X(20010820)11:16<2173:DO(>2.0.ZU;2-5
Abstract
Starting from Ro-25-6981 as a lead compound, highly potent and selective NR 1/2B subtype selective NMDA receptor antagonists, with low activity at alph a (1) adrenergic receptors were developed. (C) 2001 Elsevier Science Ltd. A ll rights reserved.